The nervous Rebel troopers aim their weapons. Suddenly a tremendous blast opens up a hole in the central passageway, and a score of fearsome armored space-suited stormtroopers make their way into the smoke-filled corridor. In a few minutes, the entire passageway is ablaze with laser fire.
Further clarification, since my question was flagged as a duplicate: it is not a purely sci-fi setting, its a sci-fi fantasy, meaning that this particular universe isn't purely centered around highly powerful technologies, but highly powerful technologies with magical properties added, in this particular scenario we are also discarding any sort
6 XM-25. XM25 25mm Counter Defilade Target Engagement (CDTE) System. XM-25: a weapon made with a futuristic vision, but it fell short of expectations. The XM-25 Counter Defilade Target Engagement System—the Punisher—is a programmed airburst grenade launcher designed to strike enemy forces hiding behind cover.
The human mind is useless as a weapon. As seen in this documentary, the human mind was no match for the invaders' clubs and slingshots. Only when humanity discovered the board with a nail in it were the aliens driven off. The most powerful weapon is probably some incredibly large board with a nail in it, like solar system sized.

A "chainsword," in case you are unaware, is a type of melee weapon typically depicted in science fiction, specifically in the Warhammer 40,000 universe. It is a sword with a chain blade powered by

The Death Star's superlaser. 10. The Death Stars. Function: Planet-Destroying Laser. Built by: Galactic Empire. The most well-known superweapons, both of the Empire's Death Stars were ultimately destroyed by the Rebel Alliance, but their ability to fire planet-destroying lasers made them dominant military forces.
Solo from Robert Mason's novels Weapon (1989) and Solo (1993) – Note, the 1996 film titled Solo is based solely on the first novel, Weapon. Sheen, a female android mysteriously programmed to guard and love Stile, a serf on the planet Proton, in the sci-fi/fantasy series Apprentice Adept (1980–82) by Piers Anthony. Ns1Vv.
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    • most powerful sci fi weapons